poly-A tail

poly-A tail
Polyadenylic acid sequence of varying length found at the 3\' end of most eukaryotic mRNAs. Histone mRNAs do not have poly-A tail. The poly-A tail is added post-transcriptionally to the primary transcript as part of the nuclear processing of RNA yielding hnRNAs with 60-200 adenylate residues in the tail. In the cytoplasm the poly-A tail on mRNAs is gradually reduced in length. The function of the poly-A tail is not clear but it is the basis of a useful technique for the isolation of eukaryotic mRNAs. The technique uses an affinity chromatography column with oligo(U) or oligo(dT) immobilized on a solid support. If cytoplasmic RNA is applied to such a column, poly-A-rich RNA (mRNA) will be retained.

Dictionary of molecular biology. 2004.

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  • poly(A)-tail — poly(A) tail. См. хвост поли (А). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • poly A tail — polyadenylate tail a sequence of about 200 adenylate residues that is added to the 3′ end of many primary mRNA transcripts during post transcriptional processing in eukaryotes. Its function seems to be protection of the RNA from enzymatic… …   Medical dictionary

  • poly-(A) tail — See: polyadenylation …   Glossary of Biotechnology

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  • poly-(A) polymerase — Enzyme that catalyses the addition of adenine residues to the 3 end of mRNA molecules, forming the characteristic poly (A) tail …   Glossary of Biotechnology

  • Queue poly (A) — Polyadénylation La polyadénylation consiste en l addition d une queue poly (A), une succession de nombreux ribonucléotides de type Adénosine (A) à l extrémité 3 des ARNm[1]. Chez les eucaryotes, cette étape s effectue dans le noyau, lors de sa… …   Wikipédia en Français

  • метод poly(T)-poly(A) — коннекторный метод Метод соединения вектора и клонируемой последовательности ДНК, заключается в присоединении с использованием терминальной трансферазы к 3 концам плазмиды полиаденильного хвоста poly(A) tail, а к 3 концам встраиваемого фрагмента… …   Справочник технического переводчика

  • Grass poly — Grass Grass, n. [OE. gras, gres, gers, AS, gr[ae]s, g[ae]rs; akin to OFries. gres, gers, OS., D., G., Icel., & Goth. gras, Dan. gr[ae]s, Sw. gr[aum]s, and prob. to E. green, grow. Cf. {Graze}.] 1. Popularly: Herbage; the plants which constitute… …   The Collaborative International Dictionary of English

  • PABPC1 — Poly(A) binding protein, cytoplasmic 1 PDB rendering based on 1cvj …   Wikipedia

  • PARN — Poly(A) specific ribonuclease (deadenylation nuclease) PDB rendering based on 1whv …   Wikipedia

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